| 肺癌患者p16基因检测的研究进展 |
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| 引用本文： | 蔡淑娟,陈建荣. 肺癌患者p16基因检测的研究进展[J]. 国际呼吸杂志, 2011, 31(18): 1410-1414. DOI: 10.3760/cma.j.issn.1673-436X.2011.018.013 |
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| 作者姓名： | 蔡淑娟 陈建荣 |
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| 作者单位： | 226001,南通大学第二附属医院呼吸科 |
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| 基金项目： | 江苏省“六大人才高峰”资助课题(06-B-18);南通市科委社会发展计划项目 |
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| 摘 要： | 细胞周期与细胞癌变密切相关,抑癌基因p16参与细胞周期调控,p16的改变可导致细胞的失控性生长,所以p16基因可成为肿瘤选择作用的治疗靶点。p16基因检测对肺癌的发病机制研究、早期诊断、预后评估和分子靶向治疗有一定帮助。
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| 关 键 词： | p16基因 肺癌 基因突变 细胞周期 |
Research progress of p16 gene detection in lung cancer |
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| CAI Shu-juan,CHEN Jian-rong. Research progress of p16 gene detection in lung cancer[J]. International Journal of Respiration, 2011, 31(18): 1410-1414. DOI: 10.3760/cma.j.issn.1673-436X.2011.018.013 |
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| Authors: | CAI Shu-juan CHEN Jian-rong |
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| Abstract: | The cell cycle is closely related with the cellular canceration. Tumor-suppressor gene p16 is involved in cell cycle regulation. The change of tumor-suppressor gene p16 could cause cells out of growth, p16 gene can become treatment target of trmor. The detection of p16 gene is helpful for the pathogenesis of lung cancer,early diagnosis,prognosis assessment and molecular-targeted therapy. |
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| Keywords: | p16 gene Lung cancer Gene mutation Cell cycle |
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