Pain-relieving action of voltaren and methindole determined in inflamed tissue

As measured on an inflamed rat paw, voltaren raised the pain sensitivity threshold 4-5-fold, whereas on a non-inflamed paw, 2-2.5-fold. The effect seen was dose-dependent. Methindole yielded to voltaren as regards analgetic action determined on inflamed tissues. The method of mechanical irritation of inflamed tissues modified by the authors provides more complete information on analgetic action of non-steroidal anti-inflammatory agents as compared to other methods.