The prior probability of autosomal linkage |
| |
| Authors: | R C ELSTON K LANGE |
| |
| Institution: | Department of Biostatistics, Genetics Curriculum and Biological Sciences Research Center, University of North Carolina at Chapel Hill, N.C. 27514;Department of Biomathematics, University of California at Los Angeles, California 90024 |
| |
| Abstract: | An expression is derived for the prior probability of linkage between a random trait locus and any one of m random marker loci, and this probability is computed form=1, 10, 20, 30, 50 and 100. A similar expression is derived for two trait loci, and computed for m=1, 10, 20 and 30. When one trait locus and 30 marker loci are being studied, a priori there is over a three-quarter probability that the trait locus should be syntenic with at least one of the markers, and about a one-half probability that there should be a linkage mappable from recombination frequencies. If two traits are studied, then the prior probability that at least one should be syntenic with one of the 30 markers is 0-94, and there is a three-quarter probability that such a linkage should be mappable. |
| |
| Keywords: | |
|
|
