Cross-neutralization tests among Cache Valley virus isolates revealing the existence of multiple subtypes |
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| Authors: | C H Calisher M S Sabattini T P Monath K L Wolff |
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| Institution: | Division of Vector-Borne Viral Diseases, U.S. Department of Health and Human Services, Fort Collins, Colorado 80522-2087. |
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| Abstract: | Maguari virus has been classified as a subtype of Cache Valley virus. Seven Bunyamwera serogroup viruses (including prototypes Cache Valley and Maguari viruses), 4 viruses shown in previous tests as close antigenic relatives of Maguari or Cache Valley viruses, and Xingu virus were cross-tested by serum dilution-plaque reduction neutralization. All viruses were distinguishable from prototypes Cache Valley and Maguari viruses. The close antigenic relationships of the Cache Valley-like viruses demonstrate that multiple subtypes of Cache Valley virus exist and suggest that such antigenic variation is a phenotypic expression of considerable genetic diversity. |
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