| 静电纺丝制备聚丙交酯超细纤维 |
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| 引用本文： | 董存海,段斌,袁晓燕,姚康德. 静电纺丝制备聚丙交酯超细纤维[J]. 生物医学工程学杂志, 2005, 22(6): 1245-1248 |
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| 作者姓名： | 董存海 段斌 袁晓燕 姚康德 |
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| 作者单位： | 天津大学,材料科学与工程学院,天津,300072 |
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| 基金项目： | 国家自然科学基金资助项目(50273027) |
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| 摘 要： | 对溶液静电纺丝制备直径小于200 nm的超细聚D,L-丙交酯(PLA)纤维进行研究,以期获得与细胞外基质尺度相近的组织修复物。以扫描电镜观察纤维形貌,结果表明溶剂是决定PLA超细纤维形成的关键因素,与丙酮相比,N,N-二甲基甲酰胺是PLA静电纺丝较为理想的溶剂。在PLA溶液中加入有机盐三乙基苯氯化铵,可使溶液的电导率大大提高,从而导致PLA超细纤维直径从500 nm降低至100~200 nm。表面活性剂Span-80的加入并没有使PLA超细纤维变得更细,而是形成了带有珠状缺陷的纤维网。
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| 关 键 词： | 静电纺丝 聚D L-丙交酯 超细纤维 形貌 直径 |
| 收稿时间： | 2004-03-02 |
| 修稿时间： | 2004-03-022004-04-20 |
Electrospinning and Morphology of Ultrafine Poly(D,L-lactide) Fibers |
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| Dong Cunhai,Duan Bin,Yuan Xiaoyan,Yao Kangde. Electrospinning and Morphology of Ultrafine Poly(D,L-lactide) Fibers[J]. Journal of biomedical engineering, 2005, 22(6): 1245-1248 |
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| Authors: | Dong Cunhai Duan Bin Yuan Xiaoyan Yao Kangde |
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| Affiliation: | School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China |
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| Abstract: | Ultrafine poly(D,L-lactide)(PLA) fibers with diameter less than 200 nm produced by electrospinning were studied to obtain tissue restoration resembling extracellular matrix.Scanning electron microscopy was used to observe the fiber morphology.Results showed that the solvent was the critical factor to determine the formation of the electrospun PLA fibers.Compared with acetone,N,Ndimethylformamide(DMF) was a better solvent for PLA to electrospin.Entrance of an organic salt,triethylbenzylammonium chlorate,led to a great increase of the conductivity of PLA/DMF solutions,so that the average fiber diameter of the electrospun PLA fibers decreased dramatically from 500 nm to 100-200 nm.The addition of surfactant,Span-80,did not improve the fiber morphology but formed beaded fiber web. |
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| Keywords: | Electrospinning Poly(D L-lactide) Ultrafine fiber Morphology Diameter |
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