抗疟新药咯萘啶对大鼠胚胎毒性的观察

抗疟新药咯萘啶以1100 mg/kg/d×1,330 mg/kg/d×3,165 mg/kg/d×3和84 mg/kg/d×3四个剂量组分别于母鼠妊娠第7天(D₇)开始每日灌胃一次。另设空白对照组及阳性对照组(敌枯双5 mg/kg/d×7)。妊娠D₂₀杀鼠检查胚胎。结果表明:咯萘啶各组均引起胚胎早期吸收率升高,并随剂量递增而增加。该药还能延迟大鼠胚胎胸骨与枕骨的骨化。各试验组中未见胎鼠外形、内脏及其它骨骼畸形。可见咯萘啶对大鼠有较明显的胚胎毒性。

THE EMBRYOTOXICITY OF A NEW ANTIMALARIAL PYRONARIDINEIN RATS

Pyronaridine was administered to rats orally in doses of 84, 165 or 330 mg/kg/d for 3 consecutive days or in a single dose of 1100 mg/kg beginning from D₇ of gestation. A known teratogen, N, N'-methylene-bis-(2-amino- 1, 3, 4- thiadiazole), dexon, at a dose of 5 mg/kg/d×7 was used as positive control. Pregnant rats were sacrificed on D₂₀ and fetuses subjected to teratological investigation. The results showed that pyronaridine at all the dosages could increase dose-dependently the rate of fetal resorption. It could also delay the ossification of occipital bone and sternum of the fetuses. Neither altered appearance nor dysmorphosis of viscera and skeleton were noted in all the test groups. It is presumed that pyronaridine possesses potent embryotoxicity under the present experimental conditions.