耐药结核病化学治疗研究的过去、现状与未来

耐药结核病的流行是当前结核病控制工作面临的主要挑战之一,严重威胁人们在结核病控制领域所取得的成就.抗结核药物是控制结核病的最有效武器,但面对耐多药结核病尤其是广泛耐药结核病明显力不从心,结核病有可能因此而再度成为“不治之症”.研制更有效的抗结核药物,设计具有抗耐药结核病的化学治疗方案,化解耐药结核病的治疗困境,迫在眉睫.作者通过回顾历史,着眼现在,展望未来,阐述耐药结核病化学治疗的若干问题,期待有助于读者对耐药结核病化学治疗研究有一个较为全面的认识,共同探索化学治疗控制耐药结核病流行的可行性.

The past,present and future of study in the chemotherapy of drug-resistant tuberculosis

The prevalence of drug resistant tuberculosis （TB） is one of the main challenges on current TB control which seriously influences the achievement people had made in this field.Anti-TB drugs are the most effective weapons in controlling TB,however,they have been obviously not enough to deal with multidrug-resistant TB,especially extensively drug resistant TB,TB is more likely to become the incurable disease again because of this reason.Therefore,it is urgent to develop more effective anti-TB drugs,design the chemotherapy regiment on drug-resistant TB and solve the difficulty in treating drug-resistant TB.The authors reviewed the history,focused on the present and looked ahead the future,elucidated several issues about treatment on drug-resistant TB and had expectation that readers would have a comprehensively understanding of chemotherapy for drug resistant TB and make efforts altogether to explore the possibility of controlling the epidemic of drug-resistant TB by chemotherapy.