γ干扰素释放试验与结核菌素皮肤试验辅助检测肺外结核病的比较

目的 比较γ干扰素释放试验与结核菌素皮肤试验在肺外结核病辅助诊断中的差异。 方法 对上海市肺科医院2012年1月至2012年6月住院治疗的100例肺外结核病患者（简称“结核病组”）及81名体检者（简称“对照组”）分别进行γ干扰素释放试验及结核菌素皮肤试验检测，统计两种检测方法的检出率，并对检出率进行比较，以P〈0.05为差异具有统计学意义。 结果 100例结核病组患者γ干扰素释放试验和结核菌素皮肤试验检测的检出率分别为80.00%（80/100），46.00%（46/100）；对两者检出率进行统计学处理，差异有统计学意义（χ^224.80，P〈0.05）。100例结核病组患者γ干扰素释放试验检测的检出率为80.00%（80/100），81名对照组γ干扰素释放试验检测的检出率为25.93%（21/81）；对两者检出率进行统计学处理，差异有统计学意义（χ^251.76，P〈0.05）。 结论 γ干扰素释放试验较结核菌素皮肤试验检测对于肺外结核病的辅助诊断有更高的敏感度及特异度。

The comparison of interferon-gamma release assay and tuberculin skin test on auxiliary detection of extrapulmonary tu-berculosis

Objective To compare the difference in the auxiliary diagnosis of extrapulmonary tuberculosis （EPTB） with interferon-gamma release assay and tuberculin skin test （TST）. Methods One hundred EPTB patients （called ‘TB group’ in short）hospitalized in Shanghai Pulmonary Hospital and 81 cases received physical exa-mination（called ‘control group’ in short）from Jan.2012 to Jun.2012 were tested with interferon-gamma release assay and TST.The detection rates of the two methods were calculated and compared, P〈0.05 was considered statistically significant. Results Of 100 patients of tuberculosis group,the detection rates were 80.00% （80/100） and 46.00% （46/100） respectively for interferon-gamma release assay and TST, and the difference was statistically significant （χ^224.80, P〈0.05）. Of 100 patients of tuberculosis group, 80 patients were positive in interferon-gamma release assay. Of 81 cases of control group, 21 cases were positive in interferon-gamma release assay. The difference of detection rate was statistically significant （χ^251.76,P〈0.05）. Conclusion Interferon-gamma release assay has higher sensitivity and specificity than TST in auxiliary diagnosis of EPTB.