Id-1蛋白在肾透明细胞癌中的表达及临床意义

目的探讨分化抑制因子-1（Id-1）蛋白在肾透明细胞癌（RCCC）中的表达及其临床意义。方法应用免疫组化二步法检测76例RCCC组织、29例癌旁正常组织中Id-1蛋白的表达情况,分析Id-1蛋白与患者临床病理特征及术后生存率之间的关系。结果 Id-1在RCCC组织和癌旁正常组织中的阳性表达率分别为90.8%、17.2%,二者比较差异有统计学意义（P〈0.05）,且Id-1的表达程度与肿瘤的病理分级、TNM分期相关（P〈0.05）,但与患者性别、年龄、有无复发等无明显相关性（P〉0.05）;生存分析显示Id-1表达阳性和阴性患者的5年生存率分别为23.5%、56.0%,两组生存率差异有统计学意义（P=0.017）。结论 Id-1的表达在RCCC中增高,Id-1阳性患者的预后较差,Id-1可作为RCCC诊断和预后判断的有效辅助指标。

Expression and clinical significance of Id-1 in renal clear cell carcinoma

Objective Study the expression of Id-1protein in renal clear cell carcinoma（RCCC）and analyze the clinical significance. Methods Immunohistochemistry were used to detect the level of Id-1protein in 76 RCCC tissues and 29 normal renal tissues.The relationship between Id-1expression level and clinical pathological data were analyzed.Survival analyses was carried in Kaplan-Meier method. Results The expression level of Id-1protein in RCCC and normal renal tissues were 90.8%,17.2%respectively,they had significant difference（P〈0.05）.Positive rates of Id-1 was correlated with the pathological grade and clinical stages of RCCC（P〈0.05）,but not with age,sex,and recurrence（P〉0.05）.The five-year survival rate of Id-1-positive and negative patients was 23.5%,56.0%respectively,the two groups had significant difference（P〈0.05）. Conclusions The expression of Id-1is higher in RCCC tissues,the prognosis of Id-1-positive patients were poor,Id-1may be a useful biomarker for diagnosing,treating RCCC and evaluating its prognosis.