| 测定病毒性心肌炎患儿柯萨奇病毒B特异性IgM的病原学意义 |
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| 引用本文： | 马官福,马连华.测定病毒性心肌炎患儿柯萨奇病毒B特异性IgM的病原学意义[J].中华儿科杂志,1996,34(1):29-31. |
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| 作者姓名： | 马官福 马连华 |
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| 作者单位： | 首都儿科研究所!100020(马官福，聂明，李家宜)，北京市感染与免疫中心实验室(马连华，刘哲伟，张霆) |
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| 摘 要： | 为探讨柯萨奇病毒B特异性IgM（CVB－IgM）的病原学意义，应用免疫印迹试验测定112例病毒性心肌炎患儿的CVB－IgM，结果是阳性33例，总阳性率为29．5％；27例正常儿童中阳性者1例，占3．7％，两者比较差异有显著意义（X2=7．813，P＜0．01）。病程小于2个月者阳性率为40％，与病程2～6个月和大于6个月者（阳性率分别为4．55％和13．33％）比较均有显著差异（X2=9．832，P＜0．01和X2=4．921，P＜0．05）。提示在临床上存在心肌炎症或心肌损伤时，测定CVB－IgM具有早期病原学诊断意义。
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| 关 键 词： | 心肌炎 免疫印迹法 柯萨奇病毒B |
Detection of IgM antibody against coxsackie virus B in patients with viral myocarditis |
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| Ma Guanfu,Ma Litanhua, Liu Zhewei,et al..Detection of IgM antibody against coxsackie virus B in patients with viral myocarditis[J].Chinese Journal of Pediatrics,1996,34(1):29-31. |
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| Authors: | Ma Guanfu Ma Litanhua Liu Zhewei |
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| Institution: | Ma Guanfu,Ma Litanhua, Liu Zhewei, et al. |
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| Abstract: | The presence of Coxsackie virus B (CVB) specific IgM antibodies was detected by usingof immunoblot assay in 112 cases of acute viral myocarditis. A 29. 5% of positive rate was observed inpatient group as compared to the rate of 3. 7 % in normal controls (P<0. 01). Of the patients evaluat-ed, a highly positive rate (40% ) was found in the group with duration of symptoms shorter than twomonths vs 4. 55% and 13. 33% of the rates observed in the groups with the duration between 2 and 6months (P< 0. 01 ) and longer than 6 months (P< 0. 05 ), respectively. The results indicate thatspecific IgM assay is a useful for etiologic study on the patients with viral myocarditis in acute phase. |
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| Keywords: | Myocarditis Immunobloting Coxsakie B Viruses |
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