| 白血病患者多向造血祖细胞培养后的透射电镜观察 |
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| 引用本文： | 陈燕,王辨明,阮幼冰,李崇渔,喻东姣.白血病患者多向造血祖细胞培养后的透射电镜观察[J].华中科技大学学报(医学版),1989(1). |
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| 作者姓名： | 陈燕 王辨明 阮幼冰 李崇渔 喻东姣 |
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| 作者单位： | 同济医科大学附属协和医院血液病研究所
(陈燕，王辨明，李崇渔)，同济医科大学超微病理研究室
(阮幼冰)，同济医科大学附属协和医院血液病研究所(喻东姣) |
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| 摘 要： | 本文运用透射电镜证明,所运用的极限稀释多向造血祖细胞(CFu—Mix)微量培养体系是体外研究造血细胞分化的重要方法。在加入一系列生长因子后,正常人骨髓细胞可向红、粒、巨核细胞系方向分化,而白血病细胞却不能,其集落细胞仍带有明显的白血病性质,提示白血病可能为多向造血祖细胞阶段的恶性变。
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| 关 键 词： | 多向造血祖细胞 正常人 白血病 透射电镜 |
Observations on CFU-Mix in Normal Adults and Leukemia by Use of Transmission Electron Microscopy |
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| Chen Yan,Wang Bianming,Ruan Youbing,Li Chongyu. Yu Dongjiao Research Institute of Hematology,Xiehe Hospital,TongjiMedical University,Wuhan.Observations on CFU-Mix in Normal Adults and Leukemia by Use of Transmission Electron Microscopy[J].Journal of Huazhong University of Science and Technology(Health Sciences),1989(1). |
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| Authors: | Chen Yan Wang Bianming Ruan Youbing Li Chongyu Yu Dongjiao Research Institute of Hematology Xiehe Hospital TongjiMedical University Wuhan |
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| Abstract: | By use of TEM, we have demonstrated that limiting dilution assay is an important tool for investigating differentiation of hemopoietic cells in vitro. When various growth factors were added to culture system, the stem cell of normal adults could differentiate into erythrocyte, granulocyte, megakaryocyte and macrophage, but leukemic progenitor cell couldn't.Its colony forming cells still present marked features of leukemia. It is, therefore, suggested that leukemia may be regarded as a malignant change in pluripotent hemopoietic progenitor cells. |
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| Keywords: | pluripotent hemopoietic progenitor cells: normal adult leukemia transmission electron microscopy |
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