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| 女性系统性红斑狼疮患者血清性激素变化 | |
| 引用本文： | 曹秀菁,叶冬青,李向培,厉小梅. 女性系统性红斑狼疮患者血清性激素变化[J]. 疾病控制杂志, 2004, 8(5): 415-417 |
| 作者姓名： | 曹秀菁 叶冬青 李向培 厉小梅 |
| 作者单位： | 1. 安徽医科大学儿少卫生与妇幼保健学系,安徽,合肥,230032 2. 安徽医科大学流行病与卫生统计学系,安徽,合肥,230032 3. 安徽省立医院风湿科,安徽,合肥,230001 |
| 基金项目： | 安徽省教育厅自然科学基金项目 (2 0 0 2kj1 6 4 )，安徽医科大学校基金资助 |
| 摘 要： | 目的 了解女性系统性红斑狼疮 (SLE)患者血清性激素水平的变化。方法 采用放射免疫法 ,测定了 2 8例女性患者的六项性激素水平 :雌二醇 (E2 )、促卵泡素 (FSH)、促黄体素 (LH)、睾酮 (T)、孕酮 (P)、催乳素 (PRL) ,并将结果分别与处于月经同期或绝经期的正常对照值加以比较。结果 有月经患者及绝经患者与正常对照值相比 ,T明显降低 (P <0 .0 0 1 ) ,活动期较非活动期患者E2 显著升高 (P <0 .0 5 )。未发现其他激素的改变。结论 SLE患者体内性激素变化对诊断和疗效观察有一定临床价值 |
| 关 键 词： | 女性 系统性红斑狼疮 血清 性激素 放射免疫法 测定 |
| 文章编号： | 1008-6013(2004)05-0415-03 |
| 修稿时间： | 2003-11-21 |
The changes of serum sex hormones in female SLE patients |
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| CAO Xiu jing,YE Dong qing,LI Xiang pei,LI Xiao mei.. The changes of serum sex hormones in female SLE patients[J]. Chinese Journal of Disease Control and Prevention, 2004, 8(5): 415-417 | |
| Authors: | CAO Xiu jing YE Dong qing LI Xiang pei LI Xiao mei. |
| Affiliation: | CAO Xiu jing,YE Dong qing,LI Xiang pei,LI Xiao mei. 1.Department of Children and Maternal health,Anhui Medical University,Hefei 230032,China, 2.Department of Epidemiology and Health Statistics,Anhui Medical University,Hefei 230032,China, 3.Department of Rheumatology,Anhui Provincial Hospital,Hefei 230001,China |
| Abstract: | Objective To explore the change of serum sex hormone in female patients with systemic lupus erythematosus (SLE). Methods The present study included 28 female patients, whose six sex hormone were detected by radio immunity assay. The results were compared with normal value at the same menstrual stage. Results The level of testosterone was found lower both in patients with menstruant and post menopause while comparing to the normal value ( P<0.001 ). The level of estradiol was found higher in patients at active stage compared to those at inactive stage (P<0.05). There were no changes in other sex hormone. Conclusions The change of sex hormone in patients with SLE is a useful indication of diagnosis and observation of curative effect. |
| Keywords: | lupus erythematosus systemic sex hormones radioimmunoassay |
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