18F-FDG PET/CT在子宫颈癌放疗靶区勾画中的价值

目的 探讨18F-FDG PET/CT在子宫颈癌放疗靶区勾画中的价值.方法 收集2015年3月至2016年10月经病理学检查证实为子宫颈鳞癌Ⅲb期患者33例,由3名放疗医师分别基于单纯CT和PET/CT融合图像勾画原发病灶大体肿瘤靶区体积(gross target volume,GTV),比较不同医师所勾画靶区的差异.结果 3名医师在单纯CT和PET/CT融合图像下定义的GTV比较差异均有统计学意义(P＜0.001).不同医师定义GTVCr差异有统计学意义(F=4.28,P＜0.001),但GTVPERT-CT差异无统计学意义(F=0.21,P=0.81).3位医师应用PET/CT图像勾画的肿瘤靶区体积变异减小(7.75 cm3 vs 24.50 cm3).结论 PET/CT融合图像可以提高靶区勾画的准确性.

Value of 18F-FDG PET/CT for delineating the target area in cervical cancer

Objective This study explored the value of ¹⁸F-FDG PET/CT for delineating the target area in cervical cancer. Methods A total of 33 patients with pathologically proven cervical squamous cell carcinoma in stage IIIB from March 2015 to October 2016 were enrolled. Based on the CT and PET/CT fusion images，3 experienced radiologists outlined the primary tumor target volume （gross target volume，GTV）and compared the differences between the target group and the group. Results Three physicians estimated significantly different GTVs based on pure CT and fusion images （P<0.001）. The LSD-t test showed a significant difference between different groups in GTVCT（F=4.28，P<0.001） but not GTVPET-CT（F=0.21，P=0.81）. Variation in tumor target volume decreased when PET/CT image delineation was used（7.75 cm³ vs 24.50 cm³）. Conclusions PET/CT fusion images can improve the accuracy of target delineation and reduce inter-observer variability.