射频消融治疗符合米兰标准的早期肝癌疗效分析

  目的   探讨射频消融治疗符合米兰标准的早期肝癌的疗效及预后危险因素。   方法   回顾性分析天津医科大学肿瘤医院72例行射频消融治疗的符合米兰标准的早期肝癌患者病例，评估其术后恢复情况，分析复发率、生存率及预后危险因素。   结果   72例患者术后并发症轻微且恢复迅速，术后1、2、3年累积复发率分别为12.50%、20.83%和33.33%；1、2、3年累积生存率分别为93.06%、87.50%、79.17%。多因素分析提示肿瘤大小与复发密切相关，肿瘤大小与术前白蛋白水平是影响总生存的独立危险因素。   结论   射频消融术治疗符合米兰标准的早期肝癌，近远期效果良好。肿瘤大小是复发的独立危险因素，肿瘤大小与术前白蛋白水平是影响总生存的重要因素。 

Efficacy analysis of radiofrequency ablation in the treatment of early-stage hepatocel-lular carcinoma within the Milan criteria

Objective:To assess efficiency of radiofrequency ablation (RFA) in the treatment of early-stage hepatocellular carcinoma within the Milan criteria and analyze prognostic factors. Methods:Reviews were conducted on clinical data of 72 patients with early-stage hepatocellular carcinoma meeting the Milan criteria who underwent RFA in Tianjin Medical University Cancer Institute and Hos-pital. Recovery status after RFA was assessed, as well as recurrence rate, survival rate, and risk factors associated with prognosis were analyzed. Results:Slight post-RFA complications were observed, and all 72 patients recovered rapidly. For 1-, 2-, and 3-year cumulative recurrence rates, computed values reached 12.50%, 20.83%, and 33.33%, respectively. For 1-, 2-, and 3-year cumulative survival rates, computed values totaled 93.06%, 87.50%, and 79.17%, respectively. Multivariate analysis showed that tumor size was closely associat-ed with recurrence and that tumor size and serum albumin levels before RFA were predictive factors for overall survival. Conclusion:RFA is an effective method in treatment of early-stage hepatocellular carcinoma within the Milan criteria. Tumor size is an indepen-dent risk factor of recurrence and along with preoperative serum albumin levels, it is a significant factor affecting overall survival of pa-tients.