肢体软组织肉瘤外科切缘的研究现状及进展

综合模式下的保肢手术是肢体软组织肉瘤治疗的发展趋势。切缘状态决定了外科治疗的质量，还将影响辅助治疗的决策。随着肿瘤治疗理念的改变和辅助治疗手段的发展，软组织肉瘤手术范围逐渐缩小。切缘阴性是软组织肉瘤外科治疗的基本目标，但对安全切缘并无统一的标准。若肿瘤邻近重要的血管、神经或骨骼，为保留肢体的功能，可以考虑边缘切除联合辅助治疗，尤其是术前放疗。在制定术前计划时，需要综合考虑肿瘤的病理学类型、肿瘤的部位、屏障结构的影响以及肿瘤对辅助治疗的反应。

Present perceptions and trends of surgical margin in soft tissue sarcoma in limbs and trunk

Limb salvage surgery with comprehensive treatment is the standard care for soft tissue sarcoma in the limbs and trunk. Marginal status is a key factor in determining the quality of surgical treatment, as well as in guiding the selection of adjuvant therapies. The goal of surgery is to obtain an appropriately negative margin, although no consensus exists regarding the adequate thickness of normal tissue cuff. With the development of auxiliary treatments, surgery for soft tissue sarcoma is becoming less extensive. Marginal resection combined with adjuvant therapies may be necessary to preserve limb functions when the tumor is close to critical vessels, nerves, or bones. When preparing the preoperative plans, additional considerations should include histologic type, location, presence of barriers, and response to adjuvant therapies.