幼稚和记忆T 细胞在NSCLC 放疗患者中的表达及其预后价值 |
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引用本文: | 刘超,吴世凯,刘广贤,申戈,王微,孟祥颖,孙冰,丛阳,赵耀巍. 幼稚和记忆T 细胞在NSCLC 放疗患者中的表达及其预后价值[J]. 中国肿瘤临床, 2017, 44(4): 159-162. DOI: 10.3969/j.issn.1000-8179.2017.04.411 |
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作者姓名: | 刘超 吴世凯 刘广贤 申戈 王微 孟祥颖 孙冰 丛阳 赵耀巍 |
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作者单位: | 安徽医科大学解放军307 临床学院肿瘤中心(北京市100071) |
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摘 要: | 目的 探讨幼稚和记忆T细胞在非小细胞肺癌(non-small cell lung cancer,NSCLC)放疗患者外周血中的表达及其与预后的关系。 方法 采用流式细胞仪检测2014年9月至2016年5月解放军307医院40例接受放疗的NSCLC首诊患者,治疗前外周血中幼稚CD4+T细胞、记忆CD4+T细胞、幼稚CD8+T细胞、记忆CD8+T细胞,与14例健康人进行对比,并分析其与临床病理特征及预后的关系。 结果 与健康组相比,NSCLC患者幼稚CD4+T细胞下降(P=0.031),记忆CD4+T细胞和记忆CD8+T细胞升高(P=0.014、0.005)。与不吸烟患者相比,吸烟患者幼稚CD4+T细胞较低(P=0.043),记忆CD4+T细胞较高(P=0.024)。与ECOG评分1~2分者相比,0分者幼稚CD8+T细胞较低(P=0.017),记忆CD8+T细胞较高(P=0.020)。单因素分析显示幼稚CD4+T细胞较高组放疗后中位无进展生存期(median progression free survival,mPFS)更长(17个月vs. 9个月,P=0.044)、记忆CD4+T细胞较高组放疗后mPFS可能更短(9个月 vs. 15个月,P=0.069)。Cox多因素分析显示幼稚CD4+T细胞与患者放疗后无进展生存期(progression free survival,PFS)独立相关(P=0.009)。 结论 NSCLC患者外周血中幼稚T细胞储备下降,记忆T细胞上升。幼稚CD4+T细胞较高可能预示放疗后PFS更长。
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关 键 词: | 非小细胞肺癌 立体定向放疗 幼稚T细胞 记忆T细胞 免疫 |
收稿时间: | 2016-12-09 |
Naive and memory T cells in patients with non-small cell lung cancer treated with ra-diotherapy and their prognostic value |
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Affiliation: | Cancer Therapy Center, 307 Clinical College of PLA, Anhui Medical University, Beijing 100071, China |
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Abstract: | Objective:To investigate the expression of naive and memory T cells in peripheral blood of patients with non-small cell lung cancer (NSCLC) treated with radiotherapy and their prognostic value. Methods:Pretreatment peripheral blood samples obtained from 40 patients with NSCLC treated via radiotherapy and 14 healthy controls were analyzed by flow cytometry for naive CD4+T cells, memo-ry CD4+T cells, naive CD8+T cells, and memory CD8+T cells. We evaluated the relationships between these cells and patient character-istics and the prognosis of patients. Results:Compared with healthy controls, patients with NSCLC showed decreased naive CD4+T cells (P=0.031) and increased memory CD4+T cells (P=0.014) and memory CD8+T cells (P=0.005). Smokers showed lower naive CD4+T cells (P=0.063) and higher memory CD4+T cells (P=0.024) than nonsmokers. Patients with good performance status exhibited decreased na-ive CD8+T cells (P=0.017) and increased memory CD8+T cells (P=0.020). Univariate analysis revealed that increased naive CD4+T cells were correlated with better progression-free survival after radiotherapy (17 vs. 9 m, P=0.044), whereas elevated memory CD4+T cells may be correlated with poor progression-free survival after radiotherapy (9 vs. 15 m, P=0.069). Multivariate analysis demonstrated that naive CD4+T cells were independently associated with progression free survival after radiotherapy (P=0.009). Conclusion:Patients with NSCLC showed decreased naive T cells and increased memory T cells. Elevated naive CD4+T cells may predict longer progression free survival after radiotherapy. |
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Keywords: | non-small cell lung cancer stereotactic body radiation therapy naive T cell memory T cell immunity |
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