脑星形细胞肿瘤微血管密度和NET-1 蛋白的表达及其相关性

 目的 探讨脑星形细胞肿瘤组织中微血管密度（MVD）和NET-1蛋白表达的意义。方法 应用免疫组化方法，检测65例脑星形细胞肿瘤组织和5例正常脑组织中，NET-1蛋白的表达以及血管内皮细胞表面抗原CD34单抗标记测定MVD，分析NET-1蛋白表达和MVD与脑星形细胞肿瘤分级关系。结果 MVD与脑星形细胞肿瘤分级相关，NET-1阳性组MVD显著高于NET-1阴性组，NET-1表达强度与MVD呈高度正相关（r1=0．6682，P〈0．05）。结论 MVD可以是判断星形细胞瘤恶性程度指标之一，NET-1可能通过促进星形细胞肿瘤组织微血管形成发挥作用。

Relationship between Microvessel Density and Expression of NET-1 Protein in Astrocytomas

Objective To investigate the relationships between the expression of NET-1 protein and the microvessel density in astrocytomas.Methods The expression of NET-1 protein and MVD marked with CD34 in 65 astrocytomas was examined by immunohistrochemistry SP method.The association between them and the relationship with pathologic classification were studied.Results MVD was correlated with pathologic classification.MVD in NET-1 positive group was higher than it in the negative group.The expression of NET-1 protein and MVD was highly correlated(rs=0.6682,P<0.05).Conclusion MVD maybe used as an indicator of determining malignant degree in astrocytomas.NET-1 might promote the forming of microvessel density in astrocytomas.