103 例胃肠道间质瘤的临床病理与预后分析

 目的 探讨胃肠道间质瘤（GISTs）的临床病理、免疫组化特征及预后相关因素。方法 103例胃肠道间质瘤患者接受手术后分析其病理形态学，观察肿瘤大小、细胞核异性型和核分裂相，并根据这些指标进行分型。检测肿瘤组织CD117和CD34免疫学表型。结果 本组103例胃肠道间质瘤中CD117阳性表达93例（90．3％），CD34阳性表达69例（70．0％），不同部位GISTs其CD117和CD34表达无显著差异（P〉0．05）。良性肿瘤患者的三年无病生存率显著地高于恶性肿瘤（P〈0.05）。结论 CD34和CD117联合使用可协助鉴别诊断GISTs。基于肿瘤大小、细胞异型性以及核分裂相等的组织形态学分型可作为诊断恶性GISTs参考指标。

Clinicopathological and Prognostic Analysis of 103 Gastrointestinal Stromal Tumors

Objective 　To investigate clinicopathologic and immunohistochemical features and prognosis-related factors in gast rointestinal st romal tumors. Methods 　One hundred and three patients with gastrointestinal stromal tumors were studied. Pathomorphology in these patients were analysed after surgical operations. GSITs were divided into Benign and malignant tumor according to tumor size ,mitosis and atypism. Immunohistochemistry was performed by the streptavidin peroxidase conjugaed method using a monoclonal antibody specifically against CD117 and CD34. Results 　Immunohistochemical expressions of CD34 and CD117 protein were detected in 90. 3 %(93/ 103) and 70. 0 %(69/ 103) patients , respectively.There were not significant differences among different sites of digestive t ract ( P > 0. 05) . 32year free-diseased survival in patients with benign tumors was significantly higher than those with malignant tumors (Ρ< 0. 05) . Conclusion 　CD117 and CD34 tumor marker may help to diagnose gastrointestinal stromal tumors. Pathomorphological features on the basis of tumor size , mitosis and atypism can provide usefulinformation for the prognosis of GST patients.