饮酒增加广西乙醛脱氢酶2 基因变异基因型携带者发生肝癌的危险性

 目的 研究乙醛脱氢酶2（ALDH2）基因多态性与饮酒因素交互作用在广西原发性肝癌发生中的作用。方法 对广西壮族自治区300例肝癌患者和292例正常对照人群进行流行病学调查研究，并用PCR-RFLP方法检测ALDH2基因型。结果 肝癌组和对照组中ALDH2变异基因型携带者分别占50．33％和47．95％（P=0．561）。肝癌人群ALDH2基因型不存在区域和民族差异（P〉0．05）。饮酒频度每周≥3次的ALDH₂²携带者发生肝癌的危险性是饮酒频度每周〈3次的ALDH2＊1携带者的3、34倍（95％CI1．75～6．41）。HBsAg阳性者发生肝癌的危险性明显高于HbsAg阴性者（P〈0．001）。结论 ALDH2基因型不构成壮汉族间肝癌发病差异的基础，频繁饮酒可能是ALDH2基因变异基因型携带者发生肝癌的危险因素。

Alcohol Consumption Increases Risk for Hepatocellular Carcinoma Among Guangxi Residents Carrying Mutant Aldehyde Dehydrogenase-2 Genotypes

Objective 　To study the relationship between aldehyde dehydrogenase-2 (ALDH2) gene polymorphism and the susceptibility of hepatocellular carcinoma ( HCC) . Methods 　Three hundred cases of HCC and 292 controls were genotyped for the ALDH2 polymorphisms by using polymerase chain reaction-rest riction fragment length polymorphism ( PCR-RFL P) method. Results 　The f requencies of ALDH2 variant genotype (ALDH₂ ^1*2/ ALDH₂²) in cases and cont rols was 50. 33 % and 47. 95 % respectively ( P = 0. 561) . There was no significant difference of ALDH2 genotype among Zhuang and Han groups in cases ( P > 0. 05) . The risk for liver cancer was 3. 34 times higher in alcoholics ( ≥3 times drinking per week) with ALDH2 * 2 genotype than cases carrying ALDH2 * 1 genotype while drinking less than 3 times per week (95 %CI 1. 75～6. 41) . The positive rates of HBsAg between cases and controls showed differences ,much higher in cases (84. 67 %) than those in controls (10. 27 %) . Conclusion 　The genotype aldehyde dehydrogenase-2 in different ethnicity may not influence the risk of HCC. Frequently alcoholic consumption and HBV infection might increase risk for HCC among Guangxi residents carrying mutant ALDH2 genotypes.