Ⅳa 期鼻咽癌治疗中不同化疗周期的疗效分析

 目的 对比观察不同化疗周期治疗Ⅳa期鼻咽癌生存率的影响。方法 100例Ⅳa期鼻咽癌患者随机分为两组，两组放疗方式及化疗方案相同，均用标准超分割方式放疗，总DT72~76．8Gy。对照组在放疗前、放疗中加用化疗，共化疗2周期；治疗组在放疗前、放疗中及放疗结束后加用化疗，共化疗4周期。结果 治疗组和对照组的5年总生存率分别为50％、40％；两组的无瘤生存率为44％和38％。治疗组和对照组的远地转移率分别为46％和56％。结论 两组生存率和远地转移率无明显差异，放疗结束后继续化疗有可能会提高生存率。

Comparison of Different Cycles Chemotherapy for Staging Ⅳa Nasopharyngeal

Objective 　To compare the survival rate of different cycles chemotherapy for the influence of staging Ⅳa nasopharyngeal. Methods 　One hundred patient s with staging Ⅳa nasopharyngeal were divided into two group s : treatment group and cont rol group. All patients were given the same radiotherapy (hyperf ractionation radiotherapy , DT : 72～76. 8 Gy) and received chemotherapy of same regimen. Patients in control group received two cycles chemotherapy before and during radiotherapy. Patients in treatment group received four cycles before , during and after radiotherapy. Results 　The 52year survival rates of treatment group and control group were 50 % and 40 % , disease-free survival rates were 44 % and 38 % , the distance metastasis rates were 46 % and 56 % respectively. Conclusion 　The survival rates and distance metastasis rates in two groups are no significant difference. Continue chemotherapy after radiotherapy may increase the survival rate.