KAI1 、MMP-9 蛋白表达与胃癌浸润转移的关系

 目的 研究胃癌组织中KAI1、MMP-9蛋白表达，探讨它们在胃癌侵袭转移过程中的作用。方法 在71例胃癌组织及20例正常胃粘膜组织中，应用免疫组织化学SP法检测KAI1、MMP-9的蛋白表达，进而分析它们彼此之间的关系及与胃癌临床病理特征之间的关系。结果 KAI1、MMP-9在胃癌中的表达率分别为36．6％、67．6％，而20例正常胃组织中KAI1与MMP-9的阳性表达率分别为90％、45％，两组间差异有统计学意义（P〈0．05）；KAI1与MMP-9的表达均与浸润深度、淋巴结转移密切相关（P〈0．05），此外，KAI1的表达还与TNM分期有关（P〈0．05）。经统计分析KAI1与MMP-9呈负相关。结论 KAI1、MMP-9与胃癌的侵袭转移密切相关，可作为评价胃癌的进展与预后的有力指标；KAI1、MMP-9可能通过影响血管生成参与胃癌的进展过程，为临床针对胃癌的抗血管治疗提供了新的思路。

Expression of KAI1 and MMP-9 Protein and Its Relationship with Invasion and Metastasis of Gastric Carcinoma

Objective To study the expressions of KAI1 and MMP-9 protein in gastric carcinoma and explore their roles in the invasion and metastasis of gastric carcinoma. Methods The expression of KAI1 and MMP-9 were detected by irnmunohistochemistry in 71 specimens of gastric carcinoma tissues and 20 specimens of normal gastric mucosa cases. Results The positive rates of KAI1, MMP-9 in gastric carcinoma tissues were 36.6%, 67.6% respectively, the expressions of K.AI1 and MMP-9 were both correlated with depth of invasion and lymph node metastasis, KAI1 was correlated with TNM stage too; By sta- tistic analysis, the expression of KAI1 and MMP-9 is of negative correlation. Conclusion The expressions of KAI1 ,MMP-9 were significantly correlated with biological behaviors of gastric carcinoma, may become target of prognostic marker in human gastric carcinoma.