晚期非小细胞肺癌合并深静脉血栓18例临床分析

目的探讨晚期非小细胞肺癌合并深静脉血栓(deep venous thrombosis,DVT)的临床危险因素及预后,为晚期非小细胞肺癌合并DVT的预防及诊治提供临床依据。方法对吉林大学第一医院2008年7月至2010年4月收治的接受化疗的18例合并DVT的晚期非小细胞肺癌患者与同期87例不存在静脉血栓栓塞的晚期非小细胞肺癌患者的临床资料进行回顾性分析。结果单因素分析显示腺癌、存在并存疾病、D-2聚体增高、白细胞计数增高、活化部分凝血酶时间(activeated partial thromboplastin time,APTT)缩短是晚期非小细胞肺癌发生DVT的危险因素(P<0.05)。多因素logistic回归显示腺癌、存在并存疾病、D-2聚体增高、白细胞计数增高、APTT缩短是晚期非小细胞肺癌发生DVT的独立危险因素。晚期非小细胞肺癌合并DVT患者生存时间低于对照组(P<0.05)。结论腺癌、存在并存疾病、D-2聚体增高、白细胞计数增高、APTT缩短是晚期非小细胞肺癌发生DVT的独立危险因素。合并DVT提示晚期非小细胞肺癌患者预后不良。

Clinical analysis on 18 cases of advanced non-small-cell lung cancer with deep vein thrombosis

Objective To discuss the clinical risk factors and prognosis of advanced non-small-cell lung cancer with deep vein thrombosis (DVT),which may provide the clinical evidence for prevention,diagnosis and treatment of this disease.Methods We retrospectively reviewed the clinical data of patients with advanced non-small-cell lung cancer who were diagnosed with DVT and without DVT between July 2008 and April 2010 in the First Hospital of Jilin University.Results Univariate analysis showed adenocarcinoma、 Comorbidities、increased D-2dimer、increased white blood cell count,decreased APTT are risk factors of DVT in advanced non-small-cell lung cancer (P<0.05).Multivariate logistic regression showed that adenocarcinoma、Comorbidities、increased D-2dimer、increased white blood cell count,decreased APTT are independent risk factors of DVT in advanced non-small-cell lung cancer.The survival time of advanced non-small-cell lung cancer patients with DVT is lower than the patient without DVT (P<0.05).Conclusion Adenocarcinoma、Comorbidities、increased D-2dimer、increased white blood cell count,decreased APTT are risk factors of DVT in advanced non-small-cell lung cancer,DVT is a poor prognosis factor of advanced non-small-cell lung cancer.