| 银屑病患者外周血单个核细胞Th_1/Th_2细胞因子表达研究 |
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| 引用本文： | 刘元林,王刚,张晓东,徐文.银屑病患者外周血单个核细胞Th_1/Th_2细胞因子表达研究[J].中国皮肤性病学杂志,2003,17(3):167-168. |
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| 作者姓名： | 刘元林 王刚 张晓东 徐文 |
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| 作者单位： | 海军总医院皮肤科,北京,100037 |
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| 摘 要： | 目的 探讨Th1/Th2 细胞因子在银屑病发病机理中的作用。方法 应用逆转录 聚合酶链反应法 (RT PCR)半定量分析 19例正常对照和 2 2例银屑病患者外周血单个核细胞中TNFα、IFN γ和IL 4、IL 10mRNA的表达。结果 银屑病患者TNFα和IFN γ表达显著上调 (P <0 .0 1) ,而IL 4显著降低 (P <0 .0 1) ,IL 10较正常降低但无显著差异(P >0 .0 5 )。结论 Th1型细胞因子在银屑病患者中过度表达 ,可能提示银屑病免疫病理机理中的T淋巴细胞活化模式。
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| 关 键 词： | 银屑病 T辅助细胞 亚群 细胞因子 |
| 文章编号： | 1001-7089(2003)03-0167-02 |
| 修稿时间： | 2002年1月17日 |
Expression of Th1/Th2 Cytokines in the Peripheral Blood Mononuclear Cells of the Patients with Psoriasis |
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| LIU Yuan-lin,WANG Gang,ZHANG Xiao-dong,et al.Expression of Th1/Th2 Cytokines in the Peripheral Blood Mononuclear Cells of the Patients with Psoriasis[J].The Chinese Journal of Dermatovenereology,2003,17(3):167-168. |
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| Authors: | LIU Yuan-lin WANG Gang ZHANG Xiao-dong |
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| Abstract: | Objective To investigate the pathogenic effects of Th 1/Th 2 cytokines in psoriasis.Methods Using RT-PCR technique to semiquantitatively analyse the expression of the mRNA expression of TNFα,TFN-γ and IL-4,IL-10 in the PBMCs from 19 normal controls and 22 psoriatic patients.Results The mRNA expression of TNFα and IFN-γ in psoriasis was upregulated compared with normal controls(P<0.001),but the expression of IL-4 mRNA was significantly decreased.There was no significant difference,though IL-10 was decresed compared with nomal controls(P>0.05).Conclusion The overexpression of Th 1-type cytokines within the psoriatic group may indicate the mode of T lymphocyte activation contributing the immunopathogenesis of psoriasis. |
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| Keywords: | Psoriasis T Help cell Subsets Cytokine |
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