Cooperation between integrin ανβ3 and VEGFR2 in angiogenesis |
| |
Authors: | Payaningal R Somanath Nikolay L Malinin Tatiana V Byzova |
| |
Institution: | (1) Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, NB50, Lerner Research Institute, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA |
| |
Abstract: | The cross-talk between receptor tyrosine kinases and integrin receptors are known to be crucial for a number of cellular functions.
On endothelial cells, an interaction between integrin αvβ3 and VEGFR2 seems to be particularly important process during vascularization. Importantly, the functional association between
VEGFR2 and integrin αvβ3 is of reciprocal nature since each receptor is able to promote activation of its counterpart. This mutually beneficial relationship
regulates a number of cellular activities involved in angiogenesis, including endothelial cell migration, survival and tube
formation, and hematopoietic cell functions within vasculature. This article discusses several possible mechanisms reported
by different labs which mediate formation of the complex between VEGFR-2 and αvβ3 on endothelial cells. The pathological consequences and regulatory events involved in this receptor cross-talk are also presented. |
| |
Keywords: | Angiogenesis VEGFR2 Integrin Alpha v beta 3 |
本文献已被 SpringerLink 等数据库收录! |
|