The pharmacology of thebaine in the chronic spinal dog |
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Authors: | P E Gilbert W R Martin |
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Affiliation: | National Institute on Drug Abuse, Division of Research, Addiction Research Center, Lexington, Ky. 40511 U.S.A. |
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Abstract: | The effects of thebaine were studied in nondependent and morphine-dependent chronic spinal dogs as well as in chronic spinal dogs receiving thebaine chronically. Thebaine did not produce any morphine-like effects in nondependent dogs nor did it precipitate an abstinence syndrome in morphine-dependent dogs. Large doses of naltrexone precipitated a mild abstinence syndrome in dogs receiving thebaine chronically; however, no withdrawal abstinence syndrome was observed after abrupt withdrawal. Thebaine is not a morphine-like drug, nor does it produce appreciable physical dependence in the dog. |
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