米非司酮并用炔诺酮治疗更年期功能失调性子宫出血的临床观察

目的 探讨米非司酮联合炔诺酮治疗更年期功血的疗效。方法 将56例更年期功血妇女随机分为两组，观察组30例用炔诺酮2．5mg每天3次及米非司酮10mg每天1次口服，连用22d。对照组26例单用炔诺酮3．75mg每天3次口服，连用22d。用药前观测功血症状、血常规、肝肾功能、B超查子宫内膜厚度及盆腔情况。官腔镜检查或诊断性刮宫，子宫内膜作组织学病理检查。结果 观察组30例有效26例，显效2例，无效2例；对照组有效10例，显效8例，无效8例。总有效率观察组优于对照组（P〈0．05）。结论 米非司酮合用炔诺酮治疗更年期功血，可显著提高疗效。

Clinical observation of effect of mifepristone combined with norethindrone in treating dysfunctional uterine bleeding of peri-menopause

Objective To analyze the efficiency of mifepristone combined with norethindrone in treating dysfunctional uterine bleeding of peri-menopause. Methods 56 patients with dysfunctional uterine bleeding of peri-menopause were randomly divided into two groups, the study group(30 cases) and the comparision group(26 cases). The patients in the study group were treated with mifepristone in small doses combined with norethindrone. And the patients in the comparision group were treated only with norethindrone. Before treating, all the patients were observed and measured symptom of dysfunctional uterine bleeding, blood routine,the function of liver and ren.the en-dometrial thickness and pelvic by ultrasonography. Through hysteroscopy or uterine curettage of diagnosis, en-dometriums were measured by pathology. Results 26 cases in the study group were evaluated as effective,2 cases as obviously effective,and 2 cases as no effective. In the comparision group, 10 patients were evalutated as effective,8 patients as obviously effective,8 patients as no effective. The total effective rates of study group was significantly higher than those of comparison group(P < 0. 05). Conclusion It can obviously improve the curative effect that mifepristone with norethindrone treats dysfunctional uterine bleeding of peri-menopause.