卵巢低反应者应用自然周期方案体外受精-胚胎移植的价值

目的探讨自然周期方案行体外受精-胚胎移植(IVF-ET)在卵巢低反应患者的应用。方法对南京大学医学院附属鼓楼医院生殖医学中心2003年11月至2007年7月20例卵巢低反应患者采用自然周期方案进行IVF-ET的临床资料进行回顾性分析。结果20例患者共进行41个起始周期。其中11个周期取消,取消率为26.8%。30个取卵周期中27个周期获得卵子,取卵周期获卵率为90.0%。19个周期进行胚胎移植,起始周期移植胚胎率46.3%,取卵周期移植胚胎率63.3%。临床妊娠6例,其中5例已经分娩,1例流产。移植周期临床妊娠率为31.6%,移植周期分娩率为26.3%。结论自然周期方案行IVF-ET对于卵巢低反应患者是一种简单有效的治疗方法。

In vitro fertilization and embryo transfer following natural cycles in poor responders

Objective To examine the feasibility of natural cycle in vitro fertilization and embryo transfer(IVF-ET) in poor responders.Methods The results of in-vitro fertilization in natural cycles from November 2003 to July 2007 in 20 poor responders at the Reproductive Medicine Center of Drum Tower Hospital were analysed.Results Twenty poor responders underwent IVF treatment with 41 unstimulated cycles.Oocyte retrievals were cancelled in 11 out of 41 cycles(26.8%).The total number of successful oocyte retrievals was 27 out of 30 procedures(90.0%).Embryo transfer was performed in 19 patients.The percentage of embryo transfers per started cycle and per attempted oocyte retrieval was 46.3% and 63.3% respectively.A total of six clinical pregnancies were obtained(31.6% per transfer),of which five has delivered(26.3% per transfer) and one aborted.Conclusion Natural-cycle IVF treatment is an easy and effective method for poor responder patients.