药物对海拔5380m居住一年青年睡眠血氧饱和度的调节作用

目的：探讨居住海拔5000m以上地区人群睡眠血氧饱和度（SaO2)的变化以及复方红景天和乙酰唑胺的调节作用；方法：对居住海拔5380m一年的24名青年随机分为A组（红景天组）、B组（乙酰唑胺组）和C组（红景天＋乙酰唑胺组），每组8人，在服药前和服药24天后分别进行睡眠SaO2监测；结果：服药后较服药前清醒时SaO2(WSaO2)、睡眠监测过程中最低SaO2(LSaO2)和平均SaO2(MSaO2)均增高，氧减饱和度指数（DI4）及SaO2≤80％的时间占总监测时间的百分比（SIT80）均降低，差别有非常显著性（P＜0．01）；服药后B组和C组与A组比较，SIT80升高，差别有显著性（P＜0．05）；WSaO2、LSaO2、MSaO2及DI4各组间比较均无统计学意义（P＞0．05）；结论：复方红景天和乙酰唑胺均能明显提高睡眠SaO2，在减小SIT80方面复方红景天有优于乙酰唑胺的趋势，但两种药物合用并无明确的协同作用。

REGULATIVE EFFECTS OF RHOLIDA AND ACETAZOLAMIDE ON BLOOD OXYGEN SATURATION DURING SLEEP AT HIGH ALTIUTDE

To study the effects of Rholida and Acetazolamide on changes of SaO 2during sleep at high altitude. Method: 24 youths, had lived at 5 380m altitude for 1 year, were randomly divided into group A(given Rholida), group B(given acetazolamide) and group C(given Rholida+acetazolamide). The SaO 2 was determined before administration and after administration for 1 day. Results: The wSaO 2,lSaO 2 and mSaO 2were increased notably after giving drug and the level of SIT 80 was lower (P<0.01) compared with waking state in three group. The level of SIT 80 were higher (P<0.05) in B and C group compared with A group. Conclusion: The level of SaO 2 could be greatly improved by giving the Rholida and acetazolamide reseperatly but no better improved by giving Rholida + acetazolamide.