羟基磷灰石义眼台作为药物缓释载体减轻术后反应的临床观察

目的评价羟基磷灰石（HA）义眼台作为药物缓释载体减轻眼球摘除义眼台植入术后反应的效果。方法植入HA义眼台前，用地塞米松5mg，庆大霉素8万u，透明质酸酶1500U混合液浸泡HA义眼台15—20min后植入，手术步骤按常规。结果观察术后1周反应情况，52例中51例（98．07％）无疼痛或仅有轻度疼痛；44例（84．62％）结膜无水肿；36例（69．23％）无恶心；16例（30．77％）轻中度恶心；48例（92．31％）无呕吐。与对照组（43例）比较，术后疼痛、结膜水肿、恶心呕吐均较轻，其差别均有统计学意义（P〈0．001）。结论HA义眼台作为药物缓释载体植入眼球肌膜囊内能有效地控制术后反应，减轻患者痛苦。

Clinical observation of hydroxyapatite orbital implant as a carrier of slow release medicine for relief from postoperative reaction

Objective To evaluate the efficacy of hydroxyapatite orbital implant used as a carrier of slow release medicine for relief of patient from postoperative reaction.Methods The HA artificial eye was implanted after soaked in the mixed liquor of 5mg(lml) dexamethasone,80,000 units(2ml) gentamycin and 1500units hyaluronidase for 15-20 minutes,and the other procedures were performed as routine.Results The reaction within a week after surgery was observed.In all 52 patients,51 patients(98.1%) felt no pain or slight pain,44(84.6%) were not found chemosis.36(69.23%) had no nausea,while the other 16(30.77%) had only slight nausea and 48(92.31%)had no vomiting.And all above achieve better results than the controlled group.(43 cases).Conclusions HA orbital implant as a carrier for slow release medicine may effectively relieve the postoperative pain in orbital implantation.