心脑血管病患者血清LPO及SOD、GSH-PX、CAT监测及相关性的研究

目的 :探讨自由基与心脑血管疾病发病的关系。方法 :应用黄嘌呤氧化酶法和丙二醛法 ,对 10 6例冠心病 ,其中包括 2 9例心肌梗塞 ,16例心绞痛 ,6 1例陈旧性冠心病 ,31例脑血管病和 6 5例健康人 ,做血清 L PO和 SOD,GSH- PX,CAT水平的监测。结果 :冠心病、脑血管病患者血清 L PO量明显高于健康组含量 ,两组比较差异显著 (P<0 .0 1) ;冠心病组与脑血管病组的SOD、GSH- PX、CAT酶活性测定值明显低于健康组测定值 (P<0 .0 1)。结论 :心脑血管病发病过程中 ,自由基参与了组织损伤 ,机体氧化及抗氧化代谢不断进行 ,密切相关 ,因此监测 L PO及系列氧化清除酶水平 ,对疾病的发展转归有其重要意义。

Determination andcorrelative study of serum LPO

Objective To study the concern of free base and heart brain blood vessel disease.Methods Apply xanthine oxidase and third dialdehyde.To determine the serum LPO,SOD,GSH-PX and CAT level in 106 cases of coronary heart disease including 29 cases of acute myocardial infarction,16 cases of coronarism and 61 cases of previously suffered coronary heart disease,and in 31 cases of cerebrovascular disease as well as in 65 cases of healthy persons.Result Show that the serum LPO content in cardiovascular and cerebrovascular diseases was significantly higher than that in healthy control group with(P<0 01);while the activity of SOD,GSH-PX and CAT in the former were significantly lower than that in the later with(P<0 01).Conclution It can be concluded that the free radicals are involved in the tissue damage in the pathogenesis of cerebrovascular and cardiovascular diseases,and the oxidation and antioxidation of body are going on with close relationship.Determination of LPO serum level and the activity of the oxidation clearance enzymes such as SOD,GSH-PX and CAT are significant towards judging the progression of diseases.