2型糖尿病下肢血管病变与视黄醇结合蛋白4及高敏C-反应蛋白关系的研究

目的探讨2型糖尿病(T2DM)下肢血管病变患者血清视黄醇结合蛋白4(RBP4)及高敏C-反应蛋白(HsCRP)水平的变化。方法研究对象115例,其中单纯T2DM组40例,2型糖尿病下肢血管病变组40例,正常对照组35例。检测其血清RBP4、HsCRP、空腹血糖(FBG)、血压、胰岛素(FINS)、糖化血红蛋白(HbA1c)、血脂、体重指数(BMI)等。结果 HsCRP、RBP4在T2DM组均显著高于对照组(P0.01),下肢血管病变组显著高于单纯糖尿病组(P0.01),多因素Logistic回归分析显示糖尿病下肢动脉硬化的发生与年龄、病程、BP、LDL-C、HsCRP、RBP4相关。结论血清RBP4、HsCRP在糖尿病患者中显著升高,其浓度变化与糖尿病下肢血管并发症的发生发展密切相关。

Relationship between serum concentrations of retinol-binding protein 4 and high sensitive C reactive protein in T2DM patients with lower extremity atherosclerosis

Objective To investigate the levels of serum retinol-binding protein 4（RBP4） and high sensitive C reactive protein （HsCRP） in type 2 diabetic mellitus （T2DM） with lower extremity atherosclerosis. Methods We selected 115 subjects and divided them into 3 groups： normal control group,T2DM group with lower extremity atherosclerosis and simple T2DM group. Serum RBP4, HsCRP were detected and other clinical index were also tested. Results The concentrations of RBP4 and HsCRP were significantly increased in diabetic group compared with those of the control group. The concentrations of serum RBP4 and HsCRP in T2DM group with lower extremity atherosclerosis were significantly higher than in simple T2DM group. It was showed by multivariate Logistic regression analysis that lower extremity atherosclerosis in T2DM was related to age, course of disease,BP,LDL-C,HsCRP,RBP4. Conclusion The concentrations of RBP4 and HsCRP are significantly higher in T2DM patients than in nomal subjects, and the changes of RBP4 and HsCRP levels are closely related to the occurrence and development of diabetic lower extremity atherosclerosis.