冻干重组人脑利钠肽治疗顽固性心衰伴肾功能不全患者疗效观察

目的观察冻干重组人脑利钠肽治疗顽固性心衰伴肾功能不全患者疗效。方法选取2008年8月～2011年9月我院82例顽固性心衰伴肾功能的患者分为治疗组32例,对照组50例。对照组采用常规治疗,治疗组加用新活素,先给予负荷剂量1.500μg/kg静脉缓慢推注,然后0.01μg/(kg.min)静脉滴注。结果在心功能方面,治疗组较对照组改善更加明显,达到显著性水平(Z=2.1,P<0.05),对照组有效率为74.0%,而治疗组为87.5%;在肾功能、尿量、NT-proBNP和心脏超声方面,治疗组均较对照组改善更加明显,差异有统计学意义。结论冻干重组人脑利钠肽治疗顽固性心衰伴肾功能不全患者疗效显著,无明显不良反应。

Effect observation of iyophilized recombinant human brain natriuretic peptide for treatment of patients of refractory heart failure with renal inadequacy

Objective To observation the effect of rhBNP on renal inadequacy patients with refractory heart failure. Methods Selected 82 patients of refractory heart failure with renal inadequacy were randomly divided into treatment group of 32 patients and control group of 50 patients in our hospital from August 2008 to September 2011. Control group was given routine treatment while treatment group was received routine treatment plus rhBNP with an initial loading dose of 1.500 μg/kg and then a slow mainline dose of 0.01 μg/（kg.min）. Results The treatment group was obviously improved in heart function when compared with the control group, re.aching the level of significance（Z = 2.1, P 〈 0.05）,. The effective rate in the control group was 74.0% while that of the treatment group was 87.5%, and the treatment group was more obviously im- proved in renal function, Urine volume, NT-proBNP and echocardiography than those in control group, reaching the level of significance. Conclusion Effect of rhBNP for treatment on patients with refractory heart failure and renal inadequacy is evidently good without obviously adverse effect.