| 来曲唑与三苯氧胺应用于乳腺癌新辅助内分泌治疗中的比较研究 |
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| 引用本文： | 侯晓兰. 来曲唑与三苯氧胺应用于乳腺癌新辅助内分泌治疗中的比较研究[J]. 中国现代医生, 2012, 0(28): 48-49 |
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| 作者姓名： | 侯晓兰 |
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| 作者单位： | 广东医学院附属佛山市禅城区中心医院妇产科,广东佛山528031 |
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| 摘 要： | 目的比较来曲唑与三苯氧胺应用于乳腺癌新辅助内分泌治疗中临床效果。方法将我院2009年2月～2011年1月收治的93例绝经后乳腺癌患者随机分为两组,对照组45例采用三苯氧胺治疗,观察组48例采用来曲唑治疗,比较分析两组的临床效果。结果观察组的总缓解率为85.4%,明显高于对照组的66.7%(P<0.05);观察组治疗前后患者的肿瘤临床分期情况发生明显变化(P<0.05)。结论来曲唑应用于乳腺癌新辅助内分泌治疗中疗效更为满意,安全性好,是临床首选的治疗药物之一。
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| 关 键 词： | 乳腺癌 内分泌治疗 来曲唑 三苯氧胺 |
Comparative study of letrozole and tamoxifen in the neoadjuvant endocrinotherapy of breast cancer |
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| HOU Xiaolan. Comparative study of letrozole and tamoxifen in the neoadjuvant endocrinotherapy of breast cancer[J]. , 2012, 0(28): 48-49 |
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| Authors: | HOU Xiaolan |
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| Affiliation: | HOU Xiaolan Department of Obstetrics and Gynecology, Chancheng Central Hospital of Foshan City Affiliated to Guangdong Medical College, Foshan 528031, China |
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| Abstract: | Objective To compare the application of Letrozole and Tamoxifen in neoadjuvant endocrine therapy on breast cancer. Methods From February 2009 to January 2011 in our hospital, 93 cases of postmenopausal breast cancer were randomly divided into control group（45 cases）treated with Tamoxifen, and observation group （48 cases） treated with letrozole, the clinical effect of two groups were compared. Results The total remission rate of observation group was 85.4%, significantly higher than 66.7% of control group, the difference was statistically significant between two groups（P 〈 0.05）;before and after treatment, the clinical stage situation of patients changed significantly （P 〈 0.05）. Conclusion Letrozole in the neoadjuvant endocrinotherapy of breast cancer has more satisfactory effect and good safety, it is one of the preferred clini- cal therapy. |
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| Keywords: | Breast cancer Endocrine therapy Letrozole Tamoxifen |
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