| 枸杞多糖对四氧嘧啶损伤的离体大鼠胰岛细胞的保护作用 |
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| 引用本文： | 徐曼艳,张红锋,王煜飞. 枸杞多糖对四氧嘧啶损伤的离体大鼠胰岛细胞的保护作用[J]. 中药材, 2002, 25(9): 649-651 |
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| 作者姓名： | 徐曼艳 张红锋 王煜飞 |
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| 作者单位： | 1. 会东师范大学生命科学学院,上海,200062
2. 上海第一人民医院糖尿病研究室,上海,200085 |
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| 摘 要： | 目的:观察枸杞多糖(LBP)对四氧嘧啶(alloxan)诱导的胰岛细胞损害的保护作用。方法:应用体外培养的大鼠胰岛细胞,分别检测alloxan、LBP及其联合对胰岛细胞超氧化物歧化酶(SOD)活性和丙二醛(MDA)生成的影响。结果:LBP明显增强受损胰岛细胞内SOD的活性,提高了胰岛细胞的抗氧化能力,减轻了过氧化物对细胞的损伤,降低MDA的生成量。结论:LBP对alloxan损伤的离体大鼠胰岛细胞有一定的保护作用。
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| 关 键 词： | 枸杞多糖 四氧嘧啶 胰岛细胞 |
| 修稿时间： | 2002-04-29 |
The Protective Effects of Lycium barbarum Polysaccharide on Alloxan-induced Isolated Islet Cells Damage in Rats |
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| Xu Manyan,Zhang Hongfeng. The Protective Effects of Lycium barbarum Polysaccharide on Alloxan-induced Isolated Islet Cells Damage in Rats[J]. Journal of Chinese medicinal materials, 2002, 25(9): 649-651 |
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| Authors: | Xu Manyan Zhang Hongfeng |
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| Affiliation: | School of Life Science, East China Normal University, Shanghai 200062. |
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| Abstract: | Objective: To study the effects of Lycium barbarum polysaccharide (LBP) on alloxan-induced isolated islet cells damage in rats. Methods: Isolated islet cells from SD rat were cultured in vitro. SOD activity and MDA content in rat islet cells incubated with alloxan or alloxan combined LBP were measured. Results: Alloxan induced a significant decrease in SOD activity and a increase in MDA production, which were inhibited by LBP. Conclusion: LBP had protective effects on alloxan-induced isolated rat islet ceus damage. |
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| Keywords: | Lycium barbarian polysaccharide Alloxan Islet cells |
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