| 活化白细胞黏附分子与肿瘤 |
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| 引用本文： | 钟立,张秉强.活化白细胞黏附分子与肿瘤[J].黑龙江医学,2014,0(7):745-747. |
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| 作者姓名： | 钟立 张秉强 |
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| 作者单位： | 钟立 (重庆医科大学第一附属医院,重庆,400016)； 张秉强 (重庆医科大学第一附属医院,重庆,400016)； |
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| 摘 要： | 活化白细胞黏附分子（ ALCAM）是免疫球蛋白基因超家族成员，主要表达在白细胞和胸腺上皮细胞，其通过异嗜性黏附形式（ ALCAM-CD6）和同嗜性黏附形式（ ALCAM-ALCAM）介导细胞间黏附。研究表明，ALCAM参与多种肿瘤的发生发展，与恶性黑色素瘤、结肠癌、乳腺癌和神经胶质瘤等侵袭与转移密切相关。
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| 关 键 词： | 活化白细胞黏附分子 肿瘤 |
Active Leukocyte Cell Adhesion Molecule and Tumors |
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| Institution: | ZHONG Li, ZHANG Bing - qiang( The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, CHINA) |
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| Abstract: | Activated leukocyte cell adhesion molecule （ ALCAM） is a member of immunoglobulin gene super family.It is mainly ex-pressed on leucocytes and thymic epithelial cells.ALCAM mediates cell -cell interactions by both heterophilic （ ALCAM-CD6 ） and ho-mophilic（ALCAM-ALCAM）.Studies show that ALCAM plays a role on tumorigenesis and progression.ALCAM expression is closely correlated with invasion and metastasis of several human tumors , including malignant melanoma ,colon carcinoma , breast cancer and glio-blastoma. |
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| Keywords: | Activated- leukocyte cell adhesion molecule Tumor |
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