成纤维细胞生长因子-2和基质金属蛋白酶-9在鼻息肉表达及其意义

目的研究成纤维细胞生长因子-2（FGF-2）和基质金属蛋白酶-9（MMP-9）在鼻息肉中表达及其意义,探讨其在鼻息肉形成中的作用。方法观察组（30例）经鼻内镜手术治疗的鼻息肉患者的鼻息肉组织;对照组（6例）行鼻中隔矫正术患者（既往无慢性鼻-鼻窦炎病史）,钩突处黏膜作为正常对照。所选患者术前6周未使用全身或局部糖皮质激素及其他鼻用药物,分别用HE染色法和免疫组化法检测两组标本中FGF-2和MMP-9的蛋白表达情况,并对结果进行统计学分析。结果 FGF-2和MMP-9在鼻息肉中表达较正常钩突处黏膜增高。结论 FGF-2和MMP-9在鼻息肉组织中的高表达可能是促进鼻息肉形成和发展的一个重要因素。

Expression and Significance of FGF-2 and MM P-9 Gene in Nasal Polyps

Objective To investigate the expressive difference of fibroblast growth factor -2, （ FGF-2） and matrix metalloproteinase-9（ MMP-9 ） gene in nasal polyp tissue a,nd to explore the role in the formation of nasal polyps .Methods In the observation group , 30 cases with nasal polyposis had nasal polyps endoscopic operation treatment ;6 cases with nasal septum deviation （ no previous history of chronic nasal sinusitis history ） uncinate process mucosa were in the control group.The selected patients didn′t use systemic or local glucocorticoid hormones and other nasal drug before 6 weeks,respectively.HE staining and immunohistochemical method was used to detect the protein expression of FGF-2 and MMP -9 in two groups.The results were statistically analyzed.Results Fibroblast growth factor 2 （FGF-2） and matrix metalloproteinase -9 （MMP-9） has higher normal uncinate mucosal expression in nasal polyps.Conlcus oin FGF-2 and MMP -9 in nasal polyps may promote high expression of nasal polyp formation and development .