他汀类药物的多效性

他汀类药物为3-羟基-3-甲基戊二酰辅酶A还原酶抑制剂,最初用于临床是由于其降低胆固醇的作用,随着临床实践及科学研究的不断深入,发现他汀类药物还具有抗炎、改善内皮舒张功能、抗氧化、降压、稳定动脉粥样硬化斑块等作用。他汀类药物的上述作用明显降低了心脑血管疾病发生率及病死率,提高了心脑血管疾病患者的生活质量,改善了心脑血管疾病患者的预后,引起了临床医师及科研工作者的广泛关注。

The Pleiotropie Effects of Statins

Statins ,inhibitors of the 3-hydroxy-3-methylglutaryl coenzyme A reduetase ,were used to clinic for lowering serum cholesterol primarily. More and more clinical practices and scientific researches found that statins have possessed other functions, such as anti-inflammatory properties, improvement of endothelial dysfunction,antioxidant effects, antihypertensive effect, stabilization of athcrosclerotic plaques. The functions of statins above significantly decreased morbidity and mortality of patients with cardiovascular and cerebrovasculax diseases,improve their quality of life and prognosis that has attracted wide attentions by clinicians and research workers.