G6PD Varadero A New Variant of Glucose-6-Phosphate Dehydrogenase Associated with Congenital Nonspherocytic Hemolytic Anemia |
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| Authors: | M. Estrada,M. Garcí a,A. Gutié rrez,I. Quintero,and R. Gonzá lez |
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| Affiliation: | Department of Enzymology, Institute of Hematology and Immunology, Havana, Cuba;Department of Pediatrics, Institute of Hematology and Immunology, Havana, Cuba |
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| Abstract: | Abstract. A glucose-6-phosphate dehydrogenase (G6PD) variant was studied in a mulatto patient with chronic nonspherocytic hemolytic anemia. This variant has reduced activity, increased thermolability, a reduced Michaelis constant for glucose-6-phosphate, slightly increased electrophoretic mobility, a biphasic pH activity profile, high 2-deoxy-glucose-6-phosphate utilization, normal diamino nicotinamide adenine dinucleotide phosphate utilization and a peak of elution profile after G6PD B. The electrophoretic, kinetic, and chromatographic properties of this erythrocyte G6PD variant allow the conclusion that G6PD Varadero is probably a new variant. |
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