A LOW DOSE OF STREPTOZOTOCIN PREVENTS KAINIC ACID-INDUCED SEIZURES AND LETHAL EFFECTS IN THE RAT |
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| Authors: | Hyoung-Chun Kim Doo-Hyun Im Wang-Kee Jhoo Chin Kim Myung-Bok Wie |
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| Institution: | College of Pharmacy, Kangwon National University, Chunchon, Korea;*R &D Centre, Samchundang Pharmaceutical Company, Chunchon, Korea |
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| Abstract: | 1. The effect of streptozotocin (STZ), a nitric oxide (NO) donor, on kainic acid (KA)-induced neurotoxicity was examined in Sprague-Dawley rats. 2. The administration of KA (8mg/kg, i.p.) produced significant neurotoxicity accompanied with increased immuno-reactivity for Fos-related antigen in the rat hippocampus. 3. Pretreatment with STZ (15mg/kg, i.m.) significantly blocked the neurotoxicity induced by KA. 4. Thus, the neuroprotective effect of STZ may, at least in part, reflect the role of NO in inhibiting seizures. |
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| Keywords: | kainic acid neuroprotective effect nitric oxide streptozotocin |
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