鼻腔粘膜吸收庆大霉素功能的研究

用静脉内、肌肉内及鼻腔内三种给药途径给１０只狗按５ｍｇ／ｋｇ用４０ｍｇ／ｍｌ的庆大霉素，并使用双波长色谱扫描法测定０～１８０分钟血清庆大霉素的浓度，比较其生物利用度。发现鼻内给药的生物利用度为静脉注射的８０．５％，肌肉注时为４２％。鼻腔用药后１０～３０分钟血清浓度达到高峰，范围在３．７～６．６μｇ／ｍｌ，半衰期长达３小时左右，表明鼻粘膜对庆大霉素有良好的通透性，可使其迅速吸收入血，并能在血中长时间维持有效浓度。

Studies on the Nasal Absorption of Gentamycin

Study on drug absorbtive function of nasal mucosa is a new and interesting subject bridg- ing otorhinolaryngology and pharmacology. The authors applied 40mg/ml gentamycin to 10 dogs at the dose of 5mg/kg through three routes of administration,ie,intravenous,intramuscular and intranasal. The serum levels of the drug from 0 to 180 minutes after applying the drug were determined with thin-layer chromatography-scanning method and the bioavailability of three routes was counted. It was found that within 10 to 30 minutes after using gentamycin the drug concentration in the blood in- creased and reached a peak. The half-life period was about three hours.The bioavailability of the intranasal administration were 80.5%,and intramuscular 42%.It was indicated that the nasal mucosa possessed an excellent penetrance for gentamycin and let it be absorbed into blood stream quickly and maintain an effective level for a long time