乌鸡白凤丸对去卵巢大鼠骨质疏松症的影响

目的:观察乌鸡白凤丸去卵巢大鼠骨质疏松症的影响.方法:采用去卵巢的方法建立大鼠骨质疏松症模型以骨钙素,碱性磷酸酶,骨密度,血磷和血总钙等指标评价.结果:乌鸡白凤丸(1.0g·kg-1,2.0g·kg-1,4.0g·kg-1)能有效预防去势大鼠骨质丢失,增加骨密度;减缓大鼠去势所致的增重效应;能有效预防去势大鼠子宫及肾上腺萎缩;对血钙含量、碱性磷酸酶无明显影响,但可回升血磷含量;可明显升高大鼠血清雌二醇、降钙素含量,降低血清骨钙素含量,有较好的防治骨质疏松效果.结论:乌鸡白凤丸对去卵巢大鼠骨质疏松症具有一定的保护作用.

Effect of Wujibaifeng Pills on osteoporosis of ovariectonmized rat

AIM: To investigate effect of Wujibaifeng Pills (WJBFP) on osteoporosis of ovariectonmized (OVX) rat. METHODS: Ovariectonmized (OVX) rat model was established to evaluate osteoporosis of which parameters investigated included bone gla protein (BGP), alkaline phosphatase (ALP), bone minera density (BMD), Serum phosphorus and serum total calcium. RESULTS: WJBFP(1.0g/kg,2.0g/kg,4.0g/kg) could enhance the contents of serum estradiol and calcitonin, decrease serum BGP level in OVX rats; It had no effect on serum total calcium and ALP activities but increase level of serum phosphorus; It could enhance BMD, prevent OVX rat from decreasing bone loss without raising body weight; furthermore, it could inhibit both the uterus and adrenal gland atrophy. CONCLUSION: WJBFP might have better prevention on osteoporosis of ovariectionmized rats.