The clinical pathology and DNA ploidy of gastric mucosa associated lymphoid tissue (malt) lymphoma infiltrating the leiomyomas of the uterus

Objective: To investigate the clinicopathology andDNA ploidy of gastric mucosa associated lymphoidtissue (MALT) lymphoma infiltraving the leiomyomas ofthe uterus of a patient. Methods: The routine paraffinslides were cut, stained with HE, immunochcmically byABC methodusing the and stained by Feulgen method.Then the DNA ploidy of tumor cells was measured withan image cytometer. Results: In the mucosa, submucosaand the smooth muscle layer of the stomach and in theleiomyomas of the uterus there was diffusive and denseinfiltration of centrocyte-like cells. The DNAmeasurement results were that the distribution of DNAmass of lymphoma cells in stomach and in lymph nodeshad a single main aneuploidy peak each, and thedistribution of DNA mass of lymphoma cells inleiomyomas of uterus had two peaks: one of them wasthe diploid, the other aneuploid. Conclusion: The MALTlymphoma cell invasion in uterus must be differentiatedwith a primary lymphoma in the uterus, the chroniclymphocyte Icukemia in uterus and an endometrialstromal sarcoma. The present prognosis of the patientunder discussion was poor. The follow-up resultsindicated the DNA index seemed to be important forpredicting the malignancy degree and prognosis.