种植体周围炎导致骨缺损的再结合研究

目的探索种植体周围炎症所致骨缺损的治疗方法,从组织学角度评价治疗后种植体周围骨再生和再结合情况。方法Beagle犬5条,双侧下颌植入标准型Br nemark种植体30颗,建立种植体周围炎骨缺损模型,随机分组进行治疗(1)单纯去除种植体周围炎性肉芽组织;(2)植入不可吸收生物膜;(3)生物膜 骨粉植入;(4)生物膜 生物活性玻璃植入。采用X线和手术直接测量以及荧光标记组织切片和不脱钙硬组织切片,观察种植体周围骨量。采用SPSS12.0软件对数据作方差分析。结果直观测量种植体周围骨量、X线测量骨接触水平、组织学测量矿化沉积率,各组间有显著性差异,P<0.05。骨粉植入组,种植体周围能形成较多的新生骨。结论炎症导致的种植体周围骨缺损,可通过治疗手段达到缺损骨的再生。

Re-osseointegration of peri-implantitis bone defects: An experimental study in dogs

PURPOSE: To investigate the treatment methods of experimentally induced peri-implantitis bone defects, and evaluate bone regeneration and re-osseointegration around implants histologically. METHODS: 30 Brinemark standard implants were placed in 5 Beagle dogs' mandibles to establish peri-implantitis bone defect model, then bone defects were randomly treated with: (1) debridement alone; (2) debridement plus guided bone regeneration using non-absorbable membrane; (3) debridement plus non-absorbable membrane associated with bone graft; (4) debridement plus non-absorbable membrane associated with biological activity glass. Peri-implant bone augmentation was observed and detected by radiography, fluorescence light micrography, un-decalcified bones ground section and direct measurement on operation. SPSS 12.0 software package was used for ANOVA, Kruskal-Wallis test and Mann-Whiteney test. RESULTS: There were significant differences between four groups in peri-implant bone augmentation, bone contact level and bone mineralization apposition rate, P < 0.05. The group using debridement plus non-absorbable membrane associated with bone graft resulted in a greater amount of regeneration than the other treatments. CONCLUSION: Inflammation induced peri-implant bone defects can regenerate by appropriate treatment. Supported by Shanghai Municipal Science and Technology Enhancement Award (Grant No.024119072).