|
|||||
|
|
| 早期口服卡维地洛对兔陈旧性心肌梗死边缘带不应期和钠电流的影响 | |
| 引用本文： | 牛惠燕,刘念,李泱,卜军,周强,阮燕菲,张存泰,陆再英. 早期口服卡维地洛对兔陈旧性心肌梗死边缘带不应期和钠电流的影响[J]. 中国心脏起搏与心电生理杂志, 2005, 19(3): 218-221 |
| 作者姓名： | 牛惠燕 刘念 李泱 卜军 周强 阮燕菲 张存泰 陆再英 |
| 作者单位： | 1. 上海市东方医院心内科,上海,200120 2. 华中科技大学同济医学院同济医院心内科 3. 中国人民解放军301医院老年心血管病研究所 |
| 摘 要： | 研究卡维地洛(Car)对陈旧性心肌梗死(OMI)心室梗死边缘带有效不应期(ERP)及钠电流(INa)的影响。家兔按体重随机分为3组,OMI组:开胸结扎冠状动脉左回旋支;Car组:手术同OMI组,并于手术前开始服用Car0.33mg·kg1·d1;假手术(Sham)组:开胸,但不结扎冠状动脉,各组动物均喂养3月。整体心脏Langendorff灌流下记录边缘带的ERP。应用双酶法分离左心室梗死边缘带(IBZ)的心肌细胞。利用膜片钳记录在电压钳模式的INa。结果:OMI组ERP较Sham组显著延长(216.9±4.6msvs160.0±3.8ms,P<0.01),Car组ERP为179.2±9.7ms,较OMI组明显缩短。OMI组IBZ存活心肌细胞的INa的密度较Sham组显著性降低,动力学研究显示,INa半失活电压曲线V1/2移向更负,其恢复时间常数值延长,从而导致INa恢复减慢;而Car组心肌细胞的INa的密度较OMI组明显增大,P<0.05,INa稳态失活曲线和恢复曲线与Sham组无显著差异。结论:卡维地洛可以抑制OMI后心室肌ERP延长,并使INa密度增大。此可能是该药减少OMI后心律失常的发生,降低病死率的机制之一。 |
| 关 键 词： | 心血管病学 卡维地洛 陈旧性心肌梗死 边缘带 有效不应期 钠电流 家兔 |
| 文章编号： | 1007-2659(2005)03-0218-04 |
| 修稿时间： | 2004-12-20 |
Effects of Carvedilol on Refractory Period and Sodium Current of Ventricular Infarction Border Zone in Rabbits With Old Myocardial Infarction |
|
| NIU Hui-yan,LIU Nian,LI Yang,et al.. Effects of Carvedilol on Refractory Period and Sodium Current of Ventricular Infarction Border Zone in Rabbits With Old Myocardial Infarction[J]. Chinese Journal of Cardiac Pacing and Electrophysiology, 2005, 19(3): 218-221 | |
| Authors: | NIU Hui-yan LIU Nian LI Yang et al. |
| Affiliation: | NIU Hui-yan,LIU Nian,LI Yang,et al. Cardiovascular Department,East Hospital,Shanghai 200120,China |
| Abstract: | To investigate effects of carvedilol on the effective refractory period (ERP) and sodium current of ventricular infarction border zone(IBZ)in rabbit models of old myocardial infarction (OMI). Rabbits with left coronary artery ligation were prepared and allowed to recover for 3 months. Carvedilol (Car 0.33 mg·kg~(-1)·d~(-1)×3 m) was orally administered. Myocytes were isolated from IBZ of the left ventricular wall. ERP in vitro through Langendorff-perfusion was measured. Sodium current was recorded using whole-cell patch clamp technique. Results: ERP in OMI group was significantly increased than that in Sham group (216.9±4.6 ms vs 160.0±3.8 ms, P<0.01). ERP in Car group was significantly lower than that in OMI group. I_(Na) density of myocytes in IBZ was significantly decreased in OMI group than that in Sham group. V_(1/2) of steady state inactivation of I_(Na) shifted significantly in the hyperpolarizing direction, and both τ_1 and τ_2 of recovery curve of I_(Na) were longer in OMI group than those in Sham group. However, I_(Na) density in Car group was remarkably increased compared with OMI group. V_(1/2) of I_(Na) inactivation curve and τ_1 and τ_2 of recovery curve were not significantly different from OMI group. Conclusion: Carvedilol could reverse the abnormal prolongation of ERP in rabbit heart with OMI. Carvedilol may also increase I_(Na) density. Therefore, Carvedilol plays the role in antiarrhythmia in OMICardiology Carvedilol Old myocardical infarction Infarction border zone |
| Keywords: | Effective refractory period Sodium current Rabbit |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |