浅谈联合用药预防剖宫产产后出血

目的:探讨米索前列醇联合缩宫素用于剖宫产产后出血的效果及安全性。方法:择期剖宫产528例随机分为两组,观察组(米索前列醇+缩宫素)300例,于剖宫产开始舌下含化米索前列醇0.4 mg,胎儿娩出后子宫体注射缩宫素20 U;对照组(缩宫素)228例,于胎儿娩出后即刻子宫体注射缩宫素20 U。观察产后2 h出血量。结果:产后2 h平均出血量:观察组为(238.11±42.62)ml,对照组为(409.53±93.17)ml,差异有统计学意义(P<0.05)。结论:米索前列醇联合缩宫素对子宫收缩作用强于单用缩宫素,能有效减少剖宫产术中、术后出血量,是一种防治产后出血安全而高效的方法,临床上值得推广使用。

Discussion on combined therapy preventing postpartum hemorrhage in cesarean section

Objective: Discuss the effect and safety of combining misoprostol and oxytocin preventing postpartum hemorrhage in cesarean section.Methods: 528 puerperas with cesarean section were randomly divided into two groups.Observation group(misoprostol+oxytocin) 300 cases,sublingual administered misoprostol 0.4 mg in the beginning of operation,after delivery of fetus,20 U oxytocin were injected into uterus.Contrast group(oxytocin)228 cases,after delivery of fetus,20 U oxytocin were injected into uterus.Observed postpartum hemorrhage for 2 h after operation.Results: After operation,the average volume of bleeding in 2 h of observation group was(238.11±42.62)ml;contrast group was(409.53±93.17)ml.And the difference was statistically significant(P<0.05).Conclusion: Combined misoprostol and oxytocin could effectively reduce postpartum hemorrhage during an operation or after,the effect is stronger than single use of oxytocin,and it's a safety and effective method to prevent postpartum hemorrhage in cesarean section.