Expression of indoleamine 2,3-dioxygenase in nasopharyngeal carcinoma impairs the cytolytic function of peripheral blood lymphocytes |
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| Authors: | Peng Liu Bai-Lu Xie Shao-Hui Cai Yun-Wen He Ge Zhang Yan-Mei Yi Jun Du |
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| Affiliation: | (1) Department of Microbial and Biochemical Pharmacy, School of Pharmaceutical Sciences,, Sun Yat-sen University, No 132 Waihuandong Road, University Town, Guangzhou, 510006, China;(2) College of Pharmacy, Jinan University, Guangzhou, 510632, China |
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| Abstract: | Background Tumor-specific cytotoxic T cells and infiltrating lymphocytes are frequently found in tumor tissues in patients with nasopharyngeal carcinoma (NPC). Most patients with NPC, however, especially those with advanced stages, have a poor clinical prognosis despite conventional immunotherapy. The aim of this work was to examine the effect of indoleamine 2,3-dioxygenase (IDO), an immunosuppressive enzyme, on the lymphocyte function in NPC. |
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