飞行员高尿酸血症调查及危险因素分析

目的 分析飞行员高尿酸血症的发病情况,研究高尿酸血症与其他心血管疾病危险因素的关系.方法 以2005-2010年在空军总医院例行体检的2563名飞行员为研究对象,分为高尿酸(＞420tmol/L)组(n=294)和正常尿酸组(n=2269),比较其高血压、高血糖、高血脂发生率,并以飞行员血尿酸(UA)为因变量,胆固醇(CHO)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、空腹血糖(BG)、收缩压(SBP)、舒张压(DBP)、吸烟情况、体重等指标为自变量进行logistic多元回归分析,确定UA水平与这些指标的关系.结果 与正常尿酸组相比,高尿酸组高血压、高CHO、高TG、低HDL、高LDL发生率明显增高(P＜0.01).Logistic多元回归分析显示,高UA水平与TG(OR=1.637,P＜0.01)、DBP(OR=1.025,P＜0.01)、体重水平(OR=1.046,P＜0.01)关系密切.结论 飞行员血清UA水平和其他心血管疾病的危险因子密切相关.

Investigation of hyperuricemia in pilots and analysis of its risk factors

Objective The present study was to investigate the incidence of hyperuricemia in military pilots and the relationship between hyperuricemia and other related risk factors of cardiovascular(CV) diseases.Methods A total of 2563 pilots,who had undergone a regular physical examination in the Air Force General Hospital from 2005 to 2010,participated in the current study.The participants were divided into high serum uric acid(UA)(hyperuricemia >420μmol/L,n=294) and normal UA groups(n=2269).The incidence rates of hypertension,hyperglycemia,and hyperlipemia between these two groups were compared.The attributive variable was blood uric acid(UA) level of pilots.Other indices included the total cholesterol(CHO),triglycerides(TG),high density lipoprotein(HDL),low density lipoprotein(LDL),fasting blood glucose(BG),systolic blood pressure(SBP),diastolic blood pressure(DBP),smoking,body weight,and flight time as independent variable.Logistic multivariate regression analysis was conducted to determine the relationship between UA level and these indexes.Results A higher incidence rate of hyperuricemia was observed in pilots with hypertension,hypercholesterolemia,hypertriglyceridemia,low HDL,and high LDL(P<0.01),compared with that of normal UA group.The regression analysis of level of blood UA with CHO,TG,HDL,LDL,BG,SBP,DBP,and body weight suggested that high UA was closely related to TG(OR=1.637,P<0.01),DBP(OR=1.025,P<0.01) and body weight(OR=1.046,P<0.01).Conclusion The serum UA of pilots is closely related to the risk factors of other cardiovascular diseases.