基质金属蛋白酶9与肾细胞癌生物学特性之间的关系

目的探讨MMP-9与肾细胞癌生物学特性之间的关系。方法肾细胞癌患者30例,其中有淋巴结转移5例。另设健康对照10名。对患者术前采空腹血,采用ELISA方法对被研究者血浆MMP-9含量进行检测。结果肾癌患者MMP-9水平高于正常健康人,P<0.001。有淋巴结转移者MMP-9浓度远高于没有转移的患者,P<0.05。结论研究表明血浆MMP-9水平与肾细胞癌生物学特性密切相关,可作为术后判定肿瘤复发、转移的指标。

Plasma Matrix Metalloproteinase 9 (MMP-9) Level Correlate with Biological Character of Renal Cell Carcinoma

Objective Try to find the correlation between MMP-9 level and Renal cell carcinoma(RCC).Methods Fasting blood were acquired from 30 patients of renal cell carcinoma before surgery therapy.Levels of MMP-9 were determined by a sandwich ELISA method using Quantikine Human MMP-9 Immunoassay.The concentration of MMP-9 was calculated after the standard curve.The comparison between each group was made by SPSS.Results MMP-9 concentration of RCC patients was higher than healthy control(P<0.01),The levels of MMP-9 is significant difference between metastasis group(including lymph node metastasis).Conclusion These studies demonstrate an inverse relationship between plasma MMP-9 level and pathological characters of renal cell carcinoma.Higher levels of MMP-9may indicates higher pathological stage and more opportunity of metastasis.Further studies are necessary to establish its usefulness in the clinical management of these patients.Metastasis can be found and treated local or systemic in time.