Effects of acute or chronic administration of low doses of a dopamine agonist on drinking and locomotor activity in the rat |
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Authors: | Colin T Dourish Steven J Cooper |
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Institution: | (1) Department of Psychology, The Queen's University of Belfast, BT7 1NN, Northern Ireland;(2) Department of Psychology, University of Birmingham, P.O. Box 363, B 15 2TT Birmingham, England |
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Abstract: | Low doses of piribedil (0.25–5.0 mg/kg) administered acutely produced reliable decrements in locomotor activity in thirsty and non-thirsty animals, the greatest effect occurring at the highest dose. A sequence of ten daily injections of piribedil produced indications of the development of tolerance, at the two highest doses (2.5 and 5.0 mg/kg) in thirsty animals. The smallest doses used, given either acutely or chronically, produced a weak enhancement of drinking behaviour within the first 15 min of a drinking test, as shown by a reduction in latency to drink and an increase in the amount of water consumption. Tolerance did develop with respect to drinking behaviour; animals treated chronically with piribedil displayed higher levels of drinking at several dose levels when compared with acutely treated subjects. The tolerance displayed at the two highest doses could have a close affinity with that shown with regard to locomotor activity. |
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Keywords: | Chronic administration Drinking Locomotor activity Piribedil Tolerance Thirst |
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