白细胞介素-6 mRNA在内异症子宫内膜的表达变化

目的：探讨IL-6 mRNA与子宫内膜异位症发病的关系。方法：利用大鼠子宫内膜异位症（内异症）动物模型，采用逆转录聚合酶链反应（RT-PCR）技术，检测子宫内膜白细胞介素-6（IL-6）mRNA表达情况。结果：正常对照组，各时点间（2、4、6和8周）IL-6 mRNA表达无显著差异（P>0.05）。内异症模型组,在成模后（2、4、6和8周）其在位、异位子宫内膜IL-6 mRNA的表达呈增高趋势（P<0.01）。在各时点，内异症异位子宫内膜>内异症在位子宫内膜>正常子宫内膜IL-6 mRNA的表达（P<0.01）。结论：IL-6 mRNA可能与内异症的进展有关。IL-6 mRNA可能促进异位内膜的种植和生长。

Expression of IL-6 mRNA in endometrium with endometriosis

AIM: The purpose of the present study was to explore the relationship between interleukin-6 mRNA expression and endometriosis. METHODS: Using the rat model, IL-6 mRNA expression in the endometrium was examined by RT-PCR. RESULTS: The expression of IL-6 mRNA in control rats did not change at 2,4,6 and 8 weeks after sham operation ( P> 0.05), but in model rats it gradually increased at 2,4,6 and 8 weeks after endometriosis ( P< 0.01). The expression of IL-6 mRNA in uterine endometrium with endometriosis was lower than in endometriotic tissue, but higher than in endometrium from healthy controls. CONCLUSION: The IL-6 mRNA expression may contribute to the development of endometriosis . The increase in IL-6 mRNA expression may promote the implantation and growth of endometriotic tissue.